Chemotherapy Compared with Radiotherapy as the First-line Therapy of Extranodal Marginal Zone Lymphoma: A Review

Objective: To compare the efficacy and safety between chemotherapy radiotherapy as main therapy of Extranodal Marginal Zone Lymphoma (EMZL). Method: Literature searching was conducted using PubMed, ScienceDirect, Google Scholar, ProQuest, SpringerLink. All studies that met inclusion exclusion criteria were categorized based on level evidence. The data demographic patients, staging disease, type treatments, outcomes this review including number local control rate, disease-free survival overall dosage, adverse drug reaction, complication recurrence and/or relapses also reported. Result: From ten article, both first-line treatment have high complete remission rate. Local (complete remission) group ranged from 56,25%-93,9%, while in 70%-100%. Overal rate 92%-100% for 90,4%-100% group. most cataract formation, showed systemic complications (hematologic or non-hematologic). relapse cases shown Conclusion: Radiotherapy rates especially early stages extranodal marginal zone lymphoma had a relatively higher incidence ophthalmic could interfere with patient’s quality life. Therefore be considered younger patients.